Program

Program | Reception

9:30: Opening Remark
Yasuyoshi Watanabe, RIKEN CLST director

　: Chair: Kazuhiko Tanzawa, RIKEN CLST
9:40: Academic Drug Discovery Centra - Cultural Bridges Over The Valley of Death?
Per Arvidsson, Karolinska Institutet
10:10: A Private-Public Open Source Partnership for Target Definition and Validation
Michael Sundstrom, Karolinska Institutet
10:40: Structure-based development of epigenetics research tools
Takashi Umehara, RIKEN CLST

11:05: Coffee Break

　: Chair: Carsten Daub, Karolinska Institutet / RIKEN CLST
11:25: Karolinska Institutet infrastructure in Protein Structure and Drug Discovery
Karin Dahlman-Wright, Karolinska Institutet
11:55: NMR facility and protein RNA projects
Toshio Yamazaki, RIKEN CLST
12:20: Analysis of drug selectivity profile in their relevant cellular contexts by CETSA-MS
Janne Lehtiö, Karolinska Institutet

12:50: Lunch

　: Chair: Kam Zhang, RIKEN CLST
14:00: Two steps forward, one step back: Successes and Failures in Structure-based Discovery of GPCR ligands
Jens Carlsson, Stockholm University
14:30: Optimization of X-ray complex structures and binding affinity prediction by FMO
Teruki Honma, RIKEN CLST
14:55: Tuning the allosteric modulation of ion channels through computational design
Erik Lindahl, Stockholm University

15:25: Coffee Break

　: Chair: Mikako Shirouzu, RIKEN CLST
15:45: Structural biology on membrane proteins and X-ray free electron laser
So Iwata, RIKEN SPring-8 Center / Kyoto University / Imperial College UK
16:15: Establishing the molecular mechanisms of solute-carrier (SLC) transporters: from snapshots to movies
David Drew, Stockholm University
16:45: Elucidate functional structure of membrane proteins in lipid environment by electron cryo-microscopy single particle analysis
Hideki Shigematsu, RIKEN CLST
17:10: CETSA as a new strategy to understand efficacy, adverse effects and resistance development of anticancer drugs
Pär Nordlund, Karolinska Institutet
This lecture has been canceled.

17:40: Closing Remark
Hiroshi Matsumoto, RIKEN president

18:10: Reception

Reception

We would like to have a reception after the symposium.
This reception, also open for public, is arranged for further discussion, and your participation is very much welcome.
All the speakers will attend.

Starting Time: 18:10-
Fee: 3,000 JPY

Please register your participation through the Symposium Registration Page.