RIKEN Center for Life Science Technologies


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To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Animal Resource Development Unit

- Harnessing Experimental Animals - 
Towards Comprehensive Animal Resource Management, Development, and Technical Support


* Due to the reorganization starting as new centers in April 2018, this laboratory is now belong to the Center for Biosystems Dynamics Research. As for the latest information, please see the following URL below.
> The webpage of Laboratory for Animal Resource Development, Center for Biosystems Dynamics Research

Unit Leader
Hiroshi Kiyonari  Ph.D.

2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan


>>> Lab Site

Research Area

The major mission of the Animal Resource Development Unit is to integrate advanced reproductive and developmental biology technologies and environment for animal research experiments through innovative research in the development of novel experimental animal models and related technical support activities. We utilize our expertise, not only to manage the state-of-the-art SPF rodent facility at RIKEN Kobe Campus, but also to accommodate a variety of animal research needs, including animal material and resource support, technical training, and education for proper conduct of animal research. In recent years, we have established colonies of a Soricomorpha species, suncus (Suncus murinus), a metatherian species, gray short-tail opossum (Monodelphis domestica), and a reptilian species, gecko (Paroedura picta) for prospective distribution services of these new resources to the research community. In addition, in close cooperation with Genetic Engineering Team, we are facilitating joint projects to generate and distribute novel genetically engineered mice with domestic and international biomedical research community, as well as conducting original research projects in live imaging and analyses of early mouse development.

Main Publications List


A possible aid in targeted insertion of large DNA elements by CRISPR/Cas in mouse zygotes.

Nakao H, Harada T, Nakao K, Kiyonari H, Inoue K, Furuta Y, Aiba A.
Genesis., 54(2), 65-77 (2016).

Conserved and divergent expression patterns of markers of axial development in eutherian mammals

Yoshida M, Kajikawa E, Kurokawa D, Tokunaga T, Onishi A, Yonemura S, Kobayashi K, Kiyonari H, Aizawa S.
Dev Dyn., 245(1), 67-86 (2016).

Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.

Katayama A, Nakatsuka A, Eguchi J, Murakami K, Teshigawara S, Kanzaki M, Nunoue T, Hida K, Wada N, Yasunaka T, Ikeda F, Takaki A, Yamamoto K, Kiyonari H, Makino H, Wada J.
Sci Rep., 5, 16920 (2015).

Optimizing and benchmarking de novo transcriptome sequencing: from library preparation to assembly evaluation.

Hara Y, Tatsumi K, Yoshida M, Kajikawa E, Kiyonari H, Kuraku S.
BMC Genomics., 16(1), 977 (2015).

The adherens junctions control susceptibility to Staphylococcus aureus α-toxin.

Popov LM, Marceau CD, Starkl PM, Lumb JH, Shah J, Guerrera D, Cooper RL, Merakou C, Bouley DM, Meng W, Kiyonari H, Takeichi M, Galli SJ, Bagnoli F, Citi S, Carette JE, Amieva MR.
Proc Natl Acad Sci U S A., 112(46), 14337-14342 (2015).

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.

Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T.
J Biol Chem., 290(40), 24255-24266 (2015).

Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos.

Hirate Y, Hirahara S, Inoue K, Kiyonari H, Niwa H, Sasaki H.
Dev Growth Differ., 57(8), 544-556 (2015).

The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.

Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
PLoS Genet., 11(9), e1005503 (2015).

Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

Kurimoto K, Yabuta Y, Hayashi K, Ohta H, Kiyonari H, Mitani T, Moritoki Y, Kohri K, Kimura H, Yamamoto T, Katou Y, Shirahige K, Saitou M.
Cell Stem Cell, 16(5), 517-532 (2015).

IFT46 plays an essential role in cilia development.

Lee MS, Hwang KS, Oh HW, Ji-Ae K, Kim HT, Cho HS, Lee JJ, Yeong Ko J, Choi JH, Jeong YM, You KH, Kim J, Park DS, Nam KH, Aizawa S, Kiyonari H, Shioi G, Park JH, Zhou W, Kim NS, Kim CH.
Dev Biol., 400(2), 248-257 (2015).


>>>ALL Publications

Member  *concurrent

CLST was reorganized into three centers according to the RIKEN 4th Medium-Term Plan from April 1, 2018. For the latest information of Animal Resource Development Unit, please visit the following websites.

> The webpage of Laboratory for Animal Resource Development, Center for Biosystems Dynamics Research [http://www.bdr.riken.jp/en/research/labs/kiyonari-h/index.html]