RIKEN Center for Life Science Technologies


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    Latest publications from CLST.
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For Public

To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Pathophysiological and Health Science Team

―Utilizing Molecules― Translational study from animal to human


* Due to the reorganization starting as new centers in April 2018, this laboratory is now belong to the Center for Biosystems Dynamics Research. As for the latest information, please see the following URL below.
> The webpage of Laboratory for Pathophysiological and Health Science, Center for Biosystems Dynamics Research

Team Leader
Yasuyoshi Watanabe  M.D., Ph.D.

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Tel: +81-78-304-7101


Research Area

We provide core technologies to realize health sciences including very early diagnosis, patho-physiology, and preemptive medicine using imaging biomarkers closely related to disease state and pre-disease state (ahead sick), to innovate medical science with promotion of collaborations among all center members.

Main Publications List


Development of diagnostic techniques for early rheumatoid arthritis using positron emission tomography with 11C-PK11195 and 11C-ketoprofen tracers

Nozaki S, Ozaki N, Suzuki S, Goto M, Mawatari A, Nakatani Y, Hayashinaka E, Wada Y, Doi H, Watanabe Y.
Mol Imaging Biol.,, (2017).

Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome

Mizuno K, Kawatani J, Tajima K, Sasaki AT, Yoneda T, Komi M, Hirai T, Tomoda A, Joudoi T, Watanabe Y.
Neuroimage Clin., 12, 600-606 (2016).

Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome

Mizuno K, Tanaka M, Tanabe HC, Joudoi T, Kawatani J, Shigihara Y, Tomoda A, Miike T, Imai-Matsumura K, Sadato N, Watanabe Y.
Neuroimage Clin., 9, 355-368 (2015).

Synthesis of 11C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography.

Doi H, Mawatari A, Kanazawa M, Nozaki S, Nomura Y, Kitayoshi T, Akimoto K, Suzuki M, Ninomiya S, Watanabe Y.
J Org Chem, 80(12), 6250-6258 (2015).

The neural mechanisms of re-experiencing mental fatigue sensation: a magnetoencephalography study.

Ishii A, Karasuyama T, Kikuchi T, Tanaka M, Yamano E, Watanabe Y.
PloS One, 10(3), e0122455 (2015).

A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.

Cui YL, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.
Neuroimage, 108, 17-22 (2015).

Quantitative evaluation of mMate1 function based on minimally invasive measurement of tissue concentration using PET with [11C]Metformin in mouse.

Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y.
Pharm Res, in press, (2015).

[11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain.

Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y.
J Nucl Med, 55(5), 852-857 (2014).

Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study.

Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y.
J Nucl Med, 55(6), 945-950 (2014).

>>>ALL Publications

Member  *concurrent

  • >>>Curriculum vitae

CLST was reorganized into three centers according to the RIKEN 4th Medium-Term Plan from April 1, 2018. For the latest information of Pathophysiological and Health Science Team, please visit the following websites.

> The webpage of Laboratory for Pathophysiological and Health Science, Center for Biosystems Dynamics Research [http://www.bdr.riken.jp/en/research/labs/watanabe-y-health/index.html]