RIKEN Center for Life Science Technologies


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To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Bio-Function Imaging Team

* Due to the reorganization starting as new centers in April 2018, The research activities of this laboratory are handed over to the Center for Biosystems Dynamics Research. As for the latest information, please see the following URL below.
> The webpage of Center for Biosystems Dynamics Research

Team Leader
Hirotaka Onoe  Ph.D.

6-7-3 Minatojima-minamimachi, Chuo-ku Kobe, Hyogo, 650-0047, Japan
Tel: +81-78-304-7121


>>> Lab Site

Research Area

For integrative understanding of the biological phenomena in life, we develop the method of dynamic imaging for complex biological and cellular functions under living state in the normal and disease-model animals of various species, including primates. In addition, we develop the novel molecular imaging probes, which are required for drug development work together cooperatively with the Labelling Chemistry Team.

Main Publications List


Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1.

Nishimura K, Doi D, Samata B, Murayama S, Tahara T, Onoe H, Takahashi J.
Stem Cell Reports, 6(4), 511-524 (2016).

Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys.

Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H.
J Neurosci, 35(1), 84-95 (2015).

Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis.

Susaki EA, Tainaka K, Perrin D, Kishino F, Tawara T, Watanabe TM, Yokoyama C, Onoe H, Eguchi M, Yamaguchi S, Abe T, Kiyonari H, Shimizu Y, Miyawaki A, Yokota H, Ueda HR.
Cell, 157(3), 726-739 (2014).

A possible mechanism of the nucleus accumbens and ventralpallidum 5-HT1B receptors underlying the antidepressantaction of ketamine: a PET study with macaques

Yamanaka H, Yokoyama C, Mizuma H, Kurai S, Finnema S,J, Halldin C, Doi H, Onoe H.
Transl Psychiatry, 4, e342 (2014).

Imaging Epigenetic Regulation by Histone Deacetylases in the Brain using PET/MRI with 18F-FAHA

Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG
Neuroimage, 64, 630-639 (2013).

Evaluation of dopamine D2/D3 and serotonin 5-HT2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography.

Nakazawa S, Yokoyama C, Nishimura N, Horisawa T, Kawasaki A, Mizuma H, Doi H, Onoe H.
Psychopharmacology (Berl), 225(2), 329-339 (2013).

Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with (11)C-labeled 20-HETE synthase-specific inhibitor.

Kawasaki T, Marumo T, Shirakami K, Mori T, Doi H, Suzuki M, Watanabe Y, Chaki S, Nakazato A, Ago Y, Hashimoto H, Matsuda T, Baba A, Onoe H.
J Cereb Blood Flow Metab, 32(9), 1737-1746 (2012).

In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester.

Shukuri M, Takashima-Hirano M, Tokuda K, Takashima T, Matsumura K, Inoue O, Doi H, Suzuki M, Watanabe Y, Onoe H.
J Nucl Med, 52(7), 1094-1101 (2011).

Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice.

Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N.
Neurobiol Dis, 42(3), 404-414 (2011).

Establishment of in vivo brain imaging method in conscious mice.

Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H.
J Nucl Med, 51(7), 1068-1075 (2010).

Member  *concurrent

CLST was reorganized into three centers according to the RIKEN 4th Medium-Term Plan from April 1, 2018.

> The webpage of Center for Biosystems Dynamics Research [http://www.bdr.riken.jp/en/research/index.html]