RIKEN Center for Life Science Technologies


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Labs & Technologies

Next-Generation Imaging Team

We establish a new methodology for next-generation imaging diagnosis - multiple molecular imaging


* Due to the reorganization starting as new centers in April 2018, this laboratory is now belong to the Center for Biosystems Dynamics Research. As for the latest information, please see the following URL below.
> The webpage of Laboratory for Next-Generation Imaging, Center for Biosystems Dynamics Research

Team Leader
Yasuyoshi Watanabe  Ph.D.

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Tel: +81-78-304-7190


Research Area

In order to realize the multiple molecular imaging - simultaneous imaging analysis of multiple biological processes taking place in the intact living organisms, we are pursuing the development of innovative imaging methodologies, and the discovery of new imaging probes.


Development of advanced molecular imaging technologies by semiconductor Compton camera GREI 

We are developing a new gamma-ray imaging system called GREI (Gamma-Ray Emission Imaging) that is a germanium semiconductor Compton camera. GREI enables simultaneous imaging of multiple probes labeled with gamma-ray emitting radionuclides. 


Development of innovative PET technologies for multiple molecular imaging

In order to realize simultaneous imaging of multiple PET probes, we are developing new technologies by integrating the PET technology and gamma-ray spectrometry. 


Production, exploration and application of new radio-isotopes for molecular imaging

For the next-generation molecular imaging, we are producing various radio-isotopes, and pursuing the exploration for new nuclear-medicine nuclides and the applications of them. 


Drug discovery and development for the next-generation molecular imaging

We are developing new probes that are considered to be used for the diagnosis of cancer and metabolic disease, and evaluation of transplant and regenerative treatment.

*Joint research with Prof. S. Enomoto of Okayama university

Main Publications List


Visualization of biodistribution of Zn complex with antidiabetic activity using semiconductor Compton camera GREI

Masayuki Munekane, Shinji Motomura, Shinichiro Kamino, Masashi Ueda, Hiromitsu Haba, Yutaka Yoshikawa, Hiroyuki Yasui, Makoto Hiromura, Shuichi Enomoto
Biochemistry and Biophysics Reports,(5), 211-215 (2015).

64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissues.

Higashikawa K, Yagi K, Watanabe K, Kamino S, Ueda M, Hiromura M, Enomoto S.
PLoS One, 9(11), e109866 (2014).

Design and Syntheses of Highly Emissive Aminobenzopyrano-xanthene Dyes in the Visible and Far-Red Regions

Kamino, S., Murakami, M., Tanioka, M., Shirasaki, Y., Watanabe, K., Horigome, J., Ooyama, Y., Enomoto, S
Org Lett, 16(1), 258-261 (2014).

New aminobenzopyranoxanthene-based colorimetric sensor for copper(II) ions with dual-color signal detection system.

Shirasaki Y, Kamino S, Tanioka M, Watanabe K, Takeuchi Y, Komeda S, Enomoto S.
Chem Asian J, 8(11), 2609-2613 (2013).

Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms

Motomura S, Kanayama Y, Hiromura M, Fukuchi T, Ida T, Haba H, Watanabe Y, Enomoto S.
J Anal At Spectrom, 28(6), 934-939 (2013).

Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells.

Taniguchi M, Fukunaka A, Hagihara M, Watanabe K, Kamino S, Kambe T, Enomoto S, Hiromura M.
PLoS One, 8(3), e58022 (2013).

A red-emissive aminobenzopyrano-xanthene dye: elucidation of fluorescence emission mechanisms in solution and in the aggregate state.

Kamino S, Muranaka A, Murakami M, Tatsumi A, Nagaoka N, Shirasaki Y, Watanabe K, Yoshida K, Horigome J, Komeda S, Uchiyama M, Enomoto S.
Phys Chem Chem Phys, 15(6), 2131-2140 (2013).

Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway.

Fukunaka A, Kurokawa Y, Teranishi F, Sekler I, Oda K, Ackland ML, Faundez V, Hiromura M, Masuda S, Nagao M, Enomoto S, Kambe T.
J Biol Chem, 286(18), 16363-16373 (2011).

A digital signal processing module for Ge semiconductor detectors.

Fukuchi T, Arai Y, Watanabe F, Motomura S, Takeda S, Kanayama Y, Haba H, Watanabe Y, Enomoto S.
IEEE Trans Nucl Sci, 58(2), 461-467 (2011).

Reversible hydrogel formation driven by protein-peptide-specific interaction and chondrocyte entrapment.

Ito F, Usui K, Kawahara D, Suenaga A, Maki T, Kidoaki S, Suzuki H, Taiji M, Itoh M, Hayashizaki Y, Matsuda T.
Biomaterials, 31(1), 58-66 (2010).

>>>ALL Publications

Member  *concurrent

CLST was reorganized into three centers according to the RIKEN 4th Medium-Term Plan from April 1, 2018. For the latest information of Next-Generation Imaging Team, please visit the following websites.

> The webpage of Laboratory for Next-Generation Imaging, Center for Biosystems Dynamics Research [http://www.bdr.riken.jp/en/research/labs/watanabe-y-next/index.html]