RIKEN Center for Life Science Technologies


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    Latest publications from CLST.
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For Public

To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Chemical Biology Team

Promotion of life science and drug discovery by world’s first innovative chemistries.


* Due to the reorganization starting as new centers in April 2018, this laboratory is now belong to the Center for Biosystems Dynamics Research. As for the latest information, please see the following URL below.
> The webpage of Laboratory for Chemical Biology, Center for Biosystems Dynamics Research

Team Leader
Takamitsu Hosoya  Ph.D.

6-7-3 Minatojima-minamimachi, Chuo-ku Kobe, Hyogo, 650-0047, Japan
Tel: +81-(0)78-304-7130


>>> Lab Site

Research Area

In order to promote human live science and drug discovery, it is necessary to develop new methods and tools based on innovative chemistries. Through the researches under collaboration with a number of scientists of different disciplines, we are trying to develop useful PET probes for in vivo imaging of target molecules, nobel strategies for efficient PET probe synthesis, chemical tools and methods that facilitate chemical biology researches, and efficient synthetic methods of valuable compounds.

Main Publications List


Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C–S Bond Cleavage

Uetake Y, Niwa T, Hosoya T.
Org Lett, 18(11), 2758-2761 (2016).

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

Niwa T, Ochiai H, Watanabe Y, Hosoya T
J Am Chem Soc, 137(45), 14313-14318 (2015).

[11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain.

Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y.
J Nucl Med, 55(5), 852-857 (2014).

Investigation of the Effect of Active Efflux at the Blood-Brain Barrier on the Distribution of Nonsteroidal Aromatase Inhibitors in the Central Nervous System

Miyajima, M; Kusuhara, H; Takahashi, K; Takashima, T; Hosoya, T; Watanabe, Y; Sugiyama, Y
J Pharm Sci, 102(9), 3309-3319 (2013).

PET of aromatase in gastric parietal cells using 11C-vorozole.

Ozawa M, Takahashi K, Akazawa KH, Takashima T, Nagata H, Doi H, Hosoya T, Wada Y, Cui Y, Kataoka Y, Watanabe Y.
J Nucl Med, 52(12), 1964-1969 (2011).

Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole.

Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergström M, Onoe H, Långström B, Watanabe Y.
Neuroreport, 22(7), 326-330 (2011).

Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain.

Takahashi K, Yamagishi G, Hiramatsu T, Hosoya A, Onoe K, Doi H, Nagata H, Wada Y, Onoe H, Watanabe Y, Hosoya T.
Bioorg Med Chem, 19(4), 1464-1470 (2011).

Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.

Ikemoto T, Hosoya T, Takata K, Aoyama H, Hiramatsu T, Onoe H, Suzuki M, Endo M.
Diabetes, 58(12), 2802-2812 (2009).

>>>All Publications

Member  *concurrent

CLST was reorganized into three centers according to the RIKEN 4th Medium-Term Plan from April 1, 2018. For the latest information of Chemical Biology Team, please visit the following websites.

> The webpage of Laboratory for Chemical Biology, Center for Biosystems Dynamics Research [http://www.bdr.riken.jp/en/research/labs/hosoya-t/index.html]